Tuesday, February 10, 2009

Using broken transcription factors as AND logic

Yeast-2-Hybrid is a technique where gene X is placed under the control of a transcription factor TF, but TF will only become active when proteins A and B interact with each other. This same concept can use used to create a transcriptional AND gate:

gene A --> protein A
gene B --> protein B

TF is only active when proteins A and B are present. Hence, gene X =  gene A && gene B

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